Corpus ID: 44400949

Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p 38-MAPK

  title={Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p 38-MAPK},
  author={Dong Yeok Shin and Won Sup Lee and L. Jingnan and Myung Hee Kang and Chung Ho Ryu and Gi-Young Kim and Ho Sung Kang and Sung Chul Shin and Yung-Hyun Choi},
Anthocyanins belong to a class of flavonoids that exhibit important anti-oxidant and anti-inflammatory actions as well as chemotherapeutic effects. However, little is known concerning the molecular mechanisms by which these activities are exerted. In this study, we investigated the anthocyanins isolated from Vitis coignetiae Pulliat for their potential antiproliferative and apoptotic effects on human colon cancer HCT-116 cells. These anthocyanins inhibited cell viability and induce apoptotic… Expand

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