Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein.

@article{Butz2000InductionOA,
  title={Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein.},
  author={K Penelope Butz and Claudia Denk and Angela Ullmann and Martin Scheffner and Felix Hoppe-Seyler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 12},
  pages={6693-7}
}
Certain types of human papillomaviruses (HPVs) are closely linked to the development of human cancers. Herein, it is shown that intracellular targeting of the HPV16 E6 oncoprotein by E6-binding peptide aptamers resulted in the apoptotic elimination of HPV16-positive cancer cells, whereas HPV-negative cells were not affected. These results provide direct experimental evidence that the HPV E6 oncoprotein has antiapoptotic activity in HPV-positive tumor cells that is required for their survival… CONTINUE READING
77 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

Similar Papers

Loading similar papers…