Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway.

@article{Ciucci2006InductionOA,
  title={Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway.},
  author={Alessandra Ciucci and Patrizia Gianferretti and Roberto Piva and Thierry Guyot and Timothy J Snape and Stanley M. Roberts and Maria Gabriella Santoro},
  journal={Molecular pharmacology},
  year={2006},
  volume={70 5},
  pages={
          1812-21
        }
}
Nuclear factor-kappaB (NF-kappaB), a transcription factor with a critical role in promoting inflammation and cell survival, is constitutively activated in estrogen-receptor (ER)-negative breast cancer and is considered a potential therapeutic target for this type of neoplasia. We have previously demonstrated that cyclopentenone prostaglandins are potent inhibitors of NF-kappaB activation by inflammatory cytokines, mitogens, and viral infection, via direct binding and modification of the beta… CONTINUE READING

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