Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1.

@article{Berry2009InductionOA,
  title={Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1.},
  author={Emily R. Berry and Jennifer L Hardt and Jon Clardy and John R. Lurain and J Julie Kim},
  journal={Gynecologic oncology},
  year={2009},
  volume={112 2},
  pages={331-6}
}
OBJECTIVE Endometrial cancer is the most common type of gynecologic cancer in the United States. In this study, we propose that a marine sponge compound, psammaplysene A (PsA) induces apoptosis in endometrial cancer cells through forced nuclear expression of FOXO1. METHODS Ishikawa and ECC1 cells were treated with varying doses of PsA. FOXO1 protein localization was observed using immunofluorescent staining of cells. The effects of PsA on cell viability and proliferation were assessed using a… CONTINUE READING