Induction of apoptosis in MCF-7 breast carcinoma cell line by RAR and RXR selective retinoids.

@article{Toma1998InductionOA,
  title={Induction of apoptosis in MCF-7 breast carcinoma cell line by RAR and RXR selective retinoids.},
  author={Salvatore Toma and L Isnardi and Lucia Riccardi and Werner Bollag},
  journal={Anticancer research},
  year={1998},
  volume={18 2A},
  pages={935-42}
}
Induction of apoptosis in MCF-7 breast carcinoma cell line by various retinoids was measured by cytofluorimetry and DNA fragmentation assay. Retinoids with marked or high selectivity for RAR alpha, RAR beta, RAR gamma or RXR alpha were tested. All these retinoids were capable of inducing apoptosis, in a dose- and time-dependent way. MCF-7 cell line expressed RAR alpha, RAR gamma and RXRs, but not RAR beta. Compared to untreated MCF-7 cells, after 2 days of incubation with each of the selective… CONTINUE READING

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