Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

  title={Induction of apoptosis in HeLa cells by trans-activation-deficient p53.},
  author={Ygal Haupt and Sheldon Rowan and Eitan Shaulian and Karen Heather Vousden and Mary Oren},
  journal={Genes & development},
  volume={9 17},
The p53 tumor suppressor protein is a transcriptional activator, which can mediate apoptotic cell death in a variety of cell types. To determine whether sequence-specific trans-activation is a prerequisite for the induction of apoptosis by p53, the apoptotic effects of various p53 deletion mutants were monitored in an assay based on the transient transfection of HeLa cells. A truncated protein (p53dl214), containing only the first 214 amino-terminal residues of murine p53, induced extensive… CONTINUE READING


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