Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol.

Abstract

[6]-Gingerol, a major pungent ingredient found in the rhizome of ginger, has been reported to possess a strong antiinflammatory activity, which is considered to be closely associated with its cancer chemopreventive potential. [6]-Paradol, another pungent phenolic substance found in ginger and other Zingiberaceae plants, also has a vanilloid structure found in other chemopreventive phytochemicals including curcumin. In the present study, [6]-gingerol and [6]-paradol were found to exert inhibitory effects on the viability and DNA synthesis of human promyelocytic leukemia (HL-60) cells. The cytotoxic and antiproliferative effects of both compounds were associated with apoptotic cell death. The above results suggest that [6]-gingerol and [6]-paradol possess potential cytotoxic/cytostatic activities.

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@article{Lee1998InductionOA, title={Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol.}, author={Eunjung Lee and Y J Surh}, journal={Cancer letters}, year={1998}, volume={134 2}, pages={163-8} }