Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification

@article{Furlong1998InductionOA,
  title={Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification},
  author={Isla J. Furlong and Casilda Lopez Mediavilla and Rosalia Ascaso and Abelardo Lopez Rivas and Mary K. L. Collins},
  journal={Cell Death and Differentiation},
  year={1998},
  volume={5},
  pages={214-221}
}
In order to determine whether disruption of mitochondrial function could trigger apoptosis in murine haematopoietic cells, we used the potassium ionophore valinomycin. Valinomycin induces apoptosis in the murine pre-B cell line BAF3, which cannot be inhibited by interleukin-3 addition or Bcl-2 over-expression. Valinomycin triggers rapid loss of… CONTINUE READING