Induction of apoptosis by the medium-chain length fatty acid lauric acid in colon cancer cells due to induction of oxidative stress.

@article{Fauser2013InductionOA,
  title={Induction of apoptosis by the medium-chain length fatty acid lauric acid in colon cancer cells due to induction of oxidative stress.},
  author={Jane K Fauser and Geoffrey M. Matthews and Adrian G. Cummins and Gordon Stanley Howarth},
  journal={Chemotherapy},
  year={2013},
  volume={59 3},
  pages={214-24}
}
BACKGROUND Fatty acids are classified as short-chain (SCFA), medium-chain (MCFA) or long-chain and hold promise as adjunctive chemotherapeutic agents for the treatment of colorectal cancer. The antineoplastic potential of MCFA remains underexplored; accordingly, we compared the MCFA lauric acid (C12:0) to the SCFA butyrate (C4:0) in terms of their capacity to induce apoptosis, modify glutathione (GSH) levels, generate reactive oxygen species (ROS), and modify phases of the cell cycle in Caco-2… CONTINUE READING
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Sodi - um butyrate sensitizes human colon adenocarcinoma COLO 205 cells to both intrinsic and TNFalphadependent extrinsic apopto

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