Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells.

@article{Milito2006InductionOA,
  title={Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells.},
  author={Gardenia C G Milit{\~a}o and Ivana N F Dantas and Cl{\'a}udia do {\'O} Pessoa and Maria Jos{\'e} Cajazeiras Falc{\~a}o and Edilberto Rocha Silveira and Mary Anne Sousa Lima and Rui Curi and Thais Martins de Lima and Manoel Odorico de Moraes and Let{\'i}cia Veras Costa-Lotufo},
  journal={Life sciences},
  year={2006},
  volume={78 20},
  pages={
          2409-17
        }
}
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References

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TLDR
The antimitotic effects on sea urchin eggs of five known pterocarpans are reported, suggesting that the 2-methoxy substituent can be an important pharmacophoric unit.
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TLDR
Two new isoflavonoids, 7,4'-dimethoxy-isoflavonequinone and 2,4-dihydroxyflavanone (liquiritigenin), were isolated from the heartwood of Platymiscium floribundum and showed cytotoxic activity when evaluated against five human cancer cell lines in vitro.
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The present review describes several methods to characterize and differentiate between two different mechanisms of cell death, apoptosis and necrosis. Most of these methods were applied to studies of…
Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis
TLDR
delta psi m indicates that a drop in delta psi m occurs very early in thymocyte apoptosis, before DNA fragmentation, which is associated with alteration in mitochondrial structure assessed by cytofluorimetric study of NAO uptake in apoptotic cells.
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How deregulation of apoptosis may contribute to autoimmunity, cancer, and neurodegenerative disorders and strategies some viruses have evolved that interfere with the host's apoptotic pathways are described.
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Identification of three new pterocarpans (6a,11a-dihydro-6H-benzofuro[3,2-c][1]benzopyrans) from Pisum sativum infected with Fusarium solani f. sp. pisi
The isolation of three antifungal pterocarpans from Pisum sativum epicotyls infected with Fusarium solani f. sp. pisi is described. By a combination of spectroscopic and degradative techniques the…
Use of primary cultures of rat hepatocytes to predict toxicity in the early development of new chemical entities.
Flavopiridol, a Novel Cyclin-Dependent Kinase Inhibitor, in Clinical Development
TLDR
Flavopiridol is the first CDK inhibitor to enter clinical trials and displays unique anticancer properties, and does optimal future development of this drug depend on the combination with other chemotherapy.
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