Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells

@article{Colquhoun1998InductionOA,
  title={Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells},
  author={Alison Colquhoun},
  journal={IUBMB Life},
  year={1998},
  volume={45}
}
  • A. Colquhoun
  • Published 1 June 1998
  • Biology, Medicine
  • IUBMB Life
The effects of fatty acids on the induction of apoptosis were studied over a 24 hour period in Hep2 human larynx tumour cells. While oleic and linoleic acids had little effect on the apoptotic index, the polyunsaturated fatty acids α‐linolenie, γ‐linolenic, arachidonic, eicosapentaenoic and docosahexaenoic acids all induced apoptosis, beginning at ∼6 hours after fatty acid exposure. By 24 hours after exposure, the apoptotic index had reached as much as 19% in the presence of docosahexaenoic or… 

Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro

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Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid

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Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation

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Induced Apoptosis by Inhibition of Caspase 3 − 3 Fatty Acid ω Endothelin-1 Attenuates

DHA, an v3 FA, induced apoptosis in vascular smooth muscle cells in a dose-dependent manner and exerted important protective effects through the attenuation of DHA-induced caspase 3 activation and subsequent DNA fragmentation in the late stages of apoptosis.

Possible Mechanisms of ω-3 PUFA Anti-tumour Action

The current evidence supports a hypothesis that these anti-tumour effects are initiated by the ability of DHA and EPA to alter the lipid environment of the cell and in doing so modulate receptors, proteins, and lipid-derived signals originating from cell membranes.

Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition.

References