Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells
@article{Colquhoun1998InductionOA, title={Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells}, author={Alison Colquhoun}, journal={IUBMB Life}, year={1998}, volume={45} }
The effects of fatty acids on the induction of apoptosis were studied over a 24 hour period in Hep2 human larynx tumour cells. While oleic and linoleic acids had little effect on the apoptotic index, the polyunsaturated fatty acids α‐linolenie, γ‐linolenic, arachidonic, eicosapentaenoic and docosahexaenoic acids all induced apoptosis, beginning at ∼6 hours after fatty acid exposure. By 24 hours after exposure, the apoptotic index had reached as much as 19% in the presence of docosahexaenoic or…
33 Citations
Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids.
- Biology, ChemistryBiochemical pharmacology
- 2001
gamma-Linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells.
- BiologyBiochimica et biophysica acta
- 2001
Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro
- BiologyLipids in Health and Disease
- 2011
The results suggest that certain polyunsaturated fatty acids have tumoricidal action and are capable of enhancing the cytotoxic action of anti-cancer drugs specifically, on drug-resistant cells by enhancing drug uptake and reducing its efflux.
Mechanisms of enhanced apoptosis in HL-60 cells by UV-irradiated n-3 and n-6 polyunsaturated fatty acids.
- Biology, ChemistryFree radical biology & medicine
- 2003
Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid
- BiologyMolecular and Cellular Biochemistry
- 2004
The data presented show that the addition of GLA to the diet of Walker 256 tumour-bearing rats can greatly decrease the rate of development of the tumours burden, due to the accumulation of poorly metabolised acyl CoA's within the tumour cell cytoplasm which, when coupled with altered mitochondrial composition, membrane potential and ultrastructure, may be a signal for cell death.
Prevention of docosahexaenoic acid-induced cytotoxicity by phosphatidic acid in Jurkat leukemic cells: the role of protein phosphatase-1.
- Biology, ChemistryBiochimica et biophysica acta
- 2001
Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation
- BiologyCell biochemistry and function
- 2001
The data show that the presence of n‐3 PUFAs in the diet is able to significantly after the growth rate of the Walker 256 tumour, and the involvement of changes in mitochondrial membrane composition and membrane potential have been indicated for both EPA and DHA, while changes in lipid peroxidation have been identified inThe presence of EPA but not of DHA.
Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition.
- BiologyBiochemical pharmacology
- 2001
Docosahexaenoic acid induces apoptosis in Jurkat cells by a protein phosphatase-mediated process.
- BiologyBiochimica et biophysica acta
- 2001
References
The end of the (cell) line: methods for the study of apoptosis in vitro.
- BiologyMethods in cell biology
- 1995