Induction of apoptosis by fatty acid ethyl esters in HepG2 cells.

  title={Induction of apoptosis by fatty acid ethyl esters in HepG2 cells.},
  author={Hikmet Hakan Aydin and Handan A K Celik and Remziye Deveci and Sabire Karaçali and Guray Saydam and Serdar Bedii Omay and Y{\"u}cel Batur},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={43 1},
Fatty acid ethyl esters (FAEEs) are esterification products of ethanol and fatty acids which have been found particularly in the organ damaged by ethanol abuse. To evaluate any effect of FAEEs on HepG2 cells, we added FAEEs to cell culture medium. Electrophoresis of DNA from HepG2 cells exposed to 18.5 microM ethyl palmitate (EP) and 10.6 microM ethyl stearate (ES) for 24 h revealed a smear which is typical of non-specific degradation by DNA ladder assay. Apoptosis was characterized by electron… CONTINUE READING
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