Induction of apoptosis by curcumin and its implications for cancer therapy.

  title={Induction of apoptosis by curcumin and its implications for cancer therapy.},
  author={Devarajan Karunagaran and Ramachandran Rashmi and Thankayyan R Santhosh Kumar},
  journal={Current cancer drug targets},
  volume={5 2},
Curcumin (diferuloyl methane), the yellow pigment in turmeric (Curcuma longa), is a potent chemopreventive agent that inhibits proliferation of cancer cells by arresting them at various phases of the cell cycle depending upon the cell type. Curcumin-induced apoptosis mainly involves the mitochondria-mediated pathway in various cancer cells of different tissues of origin. In some cell types like thymocytes, curcumin induces apoptosis-like changes whereas in many other normal and primary cells… CONTINUE READING
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