Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model.

@article{Slaton2004InductionOA,
  title={Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model.},
  author={Joel W. Slaton and Gretchen M. Unger and Daniel T Sloper and Alan T. Davis and Khalil Ahmed},
  journal={Molecular cancer research : MCR},
  year={2004},
  volume={2 12},
  pages={712-21}
}
Protein serine/threonine kinase CK2 (formerly casein kinase 2) is a ubiquitous protein kinase that plays key roles in cell growth, proliferation, and survival. We have shown previously that its molecular down-regulation induces apoptosis in cancer cells in culture. Here, we have employed a xenograft model of prostate cancer to extend these studies to determine whether antisense CK2alpha evokes a similar response in vivo. A single dose of antisense CK2alpha oligodeoxynucleotide given directly… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…