Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells.

@article{Tsai1996InductionOA,
  title={Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells.},
  author={Judy Tsai and Mohit Jain and Chuen M. Hsieh and Won S. Lee and Masanori Yoshizumi and C. G. Patterson and Mark A. Perrella and Clare Cooke and Hao Wang and Edgar Haber and Richard Schlegel and Margaret E. Lee},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 7},
  pages={3667-70}
}
Pyrrolidinedithiocarbamate (PDTC) and N-acetylcysteine (NAC) have been used as antioxidants to prevent apoptosis in lymphocytes, neurons, and vascular endothelial cells. We report here that PDTC and NAC induce apoptosis in rat and human smooth muscle cells. In rat aortic smooth muscle cells, PDTC induced cell shrinkage, chromatin condensation, and DNA strand breaks consistent with apoptosis. In addition, overexpression of Bcl-2 suppressed vascular smooth muscle cell death caused by PDTC and NAC… CONTINUE READING

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