Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage.

@article{Tao2005InductionOA,
  title={Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage.},
  author={Weikang Tao and Victoria J South and Yun Zhou Zhang and Joseph Davide and Linda Farrell and Nancy E. Kohl and Laura Sepp-Lorenzino and Robert B. Lobell},
  journal={Cancer cell},
  year={2005},
  volume={8 1},
  pages={49-59}
}
The inhibition of KSP causes mitotic arrest by activating the spindle assembly checkpoint. While transient inhibition of KSP leads to reversible mitotic arrest, prolonged exposure to a KSP inhibitor induces apoptosis. Induction of apoptosis by the KSP inhibitor couples with mitotic slippage. Slippage-refractory cells show resistance to KSP inhibitor-mediated lethality, whereas promotion of slippage after mitotic arrest enhances apoptosis. However, attenuation of the spindle checkpoint confers… CONTINUE READING

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