Induction of apoptosis by Shiga toxins.

  title={Induction of apoptosis by Shiga toxins.},
  author={Vernon L. Tesh},
  journal={Future microbiology},
  volume={5 3},
Shiga toxins comprise a family of structurally and functionally related protein toxins expressed by Shigella dysenteriae serotype 1 and multiple serotypes of Escherichia coli. While the capacity of Shiga toxins to inhibit protein synthesis by catalytic inactivation of eukaryotic ribosomes has been well described, it is also apparent that Shiga toxins trigger apoptosis in many cell types. This review presents evidence that Shiga toxins induce apoptosis of epithelial, endothelial, leukocytic… CONTINUE READING

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