Induction of apoptosis by AN-152, a cytotoxic analog of luteinizing hormone-releasing hormone (LHRH), in LHRH-R positive human breast cancer cells is independent of multidrug resistance-1 (MDR-1) system

Abstract

Objective. More than 50% of human breast cancers express receptors for luteinizing hormone-releasing hormone (LHRH-R). These receptors can be used for targeted chemotherapy with agents like AN-152, in which doxorubicin is linked to analog [D-Lys<sup>6</sup>]LHRH. We compared the effects of AN-152 and doxorubicin in human breast cancer cells. Methods. MCF-7… (More)
DOI: 10.1007/s10549-004-8806-8

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@article{Gumlnthert2004InductionOA, title={Induction of apoptosis by AN-152, a cytotoxic analog of luteinizing hormone-releasing hormone (LHRH), in LHRH-R positive human breast cancer cells is independent of multidrug resistance-1 (MDR-1) system}, author={Andreas R. Gumlnthert and Carsten Grumlndker and Till Bongertz and Attila Nagy and Andrew V Schally and Gumlnter Emons}, journal={Breast Cancer Research and Treatment}, year={2004}, volume={87}, pages={255-264} }