Induction of apoptosis and lipogenesis in human preadipocyte cell line by n-3 PUFAs.

@article{Hanada2011InductionOA,
  title={Induction of apoptosis and lipogenesis in human preadipocyte cell line by n-3 PUFAs.},
  author={Haruka Hanada and Keiko Morikawa and Kaori Hirota and Mitsuko Nonaka and Yukari Umehara},
  journal={Cell biology international},
  year={2011},
  volume={35 1},
  pages={51-9}
}
We examined the effect of n-3 PUFAs (polyunsaturated fatty acids) on the growth and maturation of human preadipocyte cell line AML-I. On day 3 of the culture, n-3 fatty acids such as DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid), but not n-6 fatty acid LA (linoleic acid), induced growth arrest accompanied by the appearance of characteristics of apoptosis in AML-I cells at concentrations between 250 and 500 μM by Annexin V-FITC staining. In Western blotting analysis, the loss of NF… CONTINUE READING
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