Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos

@inproceedings{Lu2011InductionOA,
  title={Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos},
  author={Jenher Lu and Tzuchun Tsai and Sielin Choo and Shuyu Yeh and Renbing Tang and An Hang Yang and Hsinyu Lee and Jennkan Lu},
  booktitle={Journal of Biomedical Science},
  year={2011}
}
The tbx5 mutation in human causes Holt-Oram syndrome, an autosomal dominant condition characterized by a familial history of congenital heart defects and preaxial radial upper-limb defects. We report aberrant apoptosis and dormant cell growth over head, heart, trunk, fin, and tail of zebrafish embryos with tbx5 deficiency correspond to the dysmorphogenesis of tbx5 morphants. Wild-type zebrafish embryos at the 1-cell stage were injected with 4.3 nl of 19.4 ng of tbx5 morpholino or mismatch-tbx5… CONTINUE READING
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