Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium.

@article{Lyte2006InductionOA,
  title={Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium.},
  author={Mark Lyte and Wang Li and Noel Opitz and Ronald P Gaykema and Lisa Elane Goehler},
  journal={Physiology & behavior},
  year={2006},
  volume={89 3},
  pages={350-7}
}
Symptoms of anxiety frequently occur concomitant to the development and persistence of inflammatory bowel disease (IBD) in patients. In the present study, we utilized an animal model of IBD, infection with Citrobacter rodentium, to determine whether the infection per se can drive anxiety-like behavior. Nine-week-old CF-1 male mice were challenged orally with either saline or C. rodentium. Early in the infective process (7-8 h later), mice were tested on a hole-board open field apparatus for… CONTINUE READING
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