Induction of antimicrobial activity by antitumor substances from pine cone extract of Pinus parviflora Sieb. et Zucc.

@article{Harada1988InductionOA,
  title={Induction of antimicrobial activity by antitumor substances from pine cone extract of Pinus parviflora Sieb. et Zucc.},
  author={Hideki Harada and Hiroshi Sakagami and Kunio Konno and T Shun Sato and Nobutaka Osawa and Masato Fujimaki and Nobuhiko Komatsu},
  journal={Anticancer research},
  year={1988},
  volume={8 4},
  pages={581-7}
}
Pretreatment with two distinct antitumor substances extracted from pine cone of Pinus parviflora Sieb. et Zucc. protected mice from the lethal effects of E. coli infection. Intraperitoneal administration of these fractions transiently induced differentiation-inducing factor (DIF) with a peak at 1-2hr. The rapid decay of DIF activity from the peritoneal cavity was followed by polymorphonuclear cell (PMN) accumulation and enhancement of superoxide generation (assayed with luminol-dependent… CONTINUE READING

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