Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes.

@article{Joffre2004InductionOA,
  title={Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes.},
  author={Olivier M. Joffre and Nathalie Gorsse and Paola Romagnoli and Denis Hudrisier and Joost P. M. van Meerwijk},
  journal={Blood},
  year={2004},
  volume={103 11},
  pages={4216-21}
}
Thymus-derived regulatory T lymphocytes of CD4(+)CD25(+) phenotype regulate a large variety of beneficial and deleterious immune responses and can inhibit lethal graft-versus-host disease in rodents. In vitro, CD4(+)CD25(+) T cells require specific major histocompatibility complex (MHC)/peptide ligands for their activation, but once activated they act in an… CONTINUE READING