Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells

  title={Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells},
  author={Hiroyuki Matsue and Keiko Matsue and Michael Walters and Ko Okumura and H. Yagita and Akira Takashima},
  journal={Nature Medicine},
Dendritic cells (DCs) are special subsets of antigen-presenting cells characterized by their highly potent capacity to activate immunologically naive T cells. Here we report that DCs that are transfected with CD95 ligand (CD95L) cDNA, called 'killer' DCs, deliver death signals, instead of activation signals, to T cells after antigen-specific interaction. Injection of antigen-pulsed killer DCs into mice before sensitization induced antigen-specific immunosuppression. When administered after… CONTINUE READING


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