Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells.

@article{Mukherji1995InductionOA,
  title={Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells.},
  author={Bijay Mukherji and Nitya G. Chakraborty and Sho Yamasaki and Tetsuya Okino and Harold T. Yamase and Jonathan R. Sporn and Stephen Kurtzman and Michael T. Ergin and Juris Ozols and J Meehan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 17},
  pages={8078-82}
}
Human melanoma cells can process the MAGE-1 gene product and present the processed nonapeptide EADPTGHSY on their major histocompatibility complex class I molecules, HLA-A1, as a determinant for cytolytic T lymphocytes (CTLs). Considering that autologous antigen presenting cells (APCs) pulsed with the synthetic nonapeptide might, therefore, be immunogenic, melanoma patients whose tumor cells express the MAGE-1 gene and who are HLA-A1+ were immunized with a vaccine made of cultured autologous… CONTINUE READING

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