Induction of antibodies against human prion proteins (PrP) by DNA-mediated immunization of PrP0/0 mice.

@article{Krasemann1996InductionOA,
  title={Induction of antibodies against human prion proteins (PrP) by DNA-mediated immunization of PrP0/0 mice.},
  author={Susanne Krasemann and Martin H Groschup and Gerhard Hunsmann and Walter Bodemer},
  journal={Journal of immunological methods},
  year={1996},
  volume={199 2},
  pages={109-18}
}
Prion diseases are neurodegenerative disorders, affecting humans and animals. The human diseases include kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), and fatal familial insomnia (FFI). To generate monospecific antisera against human prion proteins we have immunized mice with DNA coding for different human prion proteins. We constructed immunization vectors expressing individual genotypes of either the cellular prion gene (PRNP) or mutant forms under… CONTINUE READING