Induction of anti-influenza immunity by modified green fluorescent protein (GFP) carrying hemagglutinin-derived epitope structure.

@article{Inoue2013InductionOA,
  title={Induction of anti-influenza immunity by modified green fluorescent protein (GFP) carrying hemagglutinin-derived epitope structure.},
  author={Yuji Inoue and Ritsuko Kubota-Koketsu and Akifumi Yamashita and Mitsuhiro Nishimura and Shoji Ideno and Ken-ichiro Ono and Yoshinobu Okuno and Kazuyoshi Ikuta},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 7},
  pages={4981-90}
}
The development of vaccination methods that can overcome the emergence of new types of influenza strains caused by escape mutations is desirable to avoid future pandemics. Here, a novel type of immunogen was designed that targeted the conformation of a highly conserved region of influenza A virus hemagglutinin (HA) composed of two separate sequences that… CONTINUE READING