Induction of angiotensin-converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility.

@article{Dahan2014InductionOA,
  title={Induction of angiotensin-converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility.},
  author={Diana Dahan and Mari Ekman and Anna-Karin Larsson-Callerfelt and Karolina M. Turczyńska and Thomas Boettger and Thomas Braun and Karl Sw{\"a}rd and Sebastian Albinsson},
  journal={American journal of physiology. Cell physiology},
  year={2014},
  volume={307 12},
  pages={C1093-101}
}
MicroRNAs have emerged as regulators of smooth muscle cell phenotype with a role in smooth muscle-related disease. Studies have shown that miR-143 and miR-145 are the most highly expressed microRNAs in smooth muscle cells, controlling differentiation and function. The effect of miR-143/145 knockout has been established in the vasculature but not in smooth muscle from other organs. Using knockout mice we found that maximal contraction induced by either depolarization or phosphatase inhibition… CONTINUE READING
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