Induction of angiotensin I-converting enzyme rat lung with Captopril (SQ 14225).

@article{Fyhrquist1980InductionOA,
  title={Induction of angiotensin I-converting enzyme rat lung with Captopril (SQ 14225).},
  author={Frej Y Fyhrquist and Terje Forslund and Ilkka Tikkanen and Carola Gr{\"o}nhagen-Riska},
  journal={European journal of pharmacology},
  year={1980},
  volume={67 4},
  pages={473-5}
}
Angiotensin I-converting enzyme (ACE, EC 2.4.15.1.) was measured in serum and in pulmonary plasma membranes of 40 spontaneously hypertensive rats (SHR, Okamoto Aoki strain), divided into 4 groups, and treated with SQ 14225 (Captopril), 0.2 mg . ml-1 in drinking water, for 0-24 weeks. Serum ACE activity increased 2.5-3 fold after 12-24 weeks of SQ 14225 treatment, paralleled by an increase of ACE concentration in purified pulmonary plasma membranes (25-52%), and in ACE concentration upon… CONTINUE READING
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