Induction of angiotensin I-converting enzyme by captopril in cultured human endothelial cells.

@article{Fyhrquist1982InductionOA,
  title={Induction of angiotensin I-converting enzyme by captopril in cultured human endothelial cells.},
  author={Frej Y Fyhrquist and Lars Hortling and Carola Gr{\"o}nhagen-Riska},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1982},
  volume={55 4},
  pages={
          783-6
        }
}
Captopril (2.0 microgram/ml) increased angiotensin-converting enzyme (ACE, kininase II) activity from 6- to 16-fold in culture medium of human endothelial cells from umbilical cord artery. Immunohistochemically detectable ACE was markedly increased in these cells when using rabbit antihuman lung ACE antiserum. This accords with either observations of increased ACE activity in serum and lungs from rats treated with captopril and shows induction of ACE biosynthesis in human vascular endothelial… CONTINUE READING
Highly Cited
This paper has 26 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 10 citations