Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments.

@article{Higgins2003InductionOA,
  title={Induction of angiogenic cytokine expression in cultured RPE by ingestion of oxidized photoreceptor outer segments.},
  author={Gareth T Higgins and Jian Wang and Peter Dockery and Philip E. Cleary and Henry Paul Redmond},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 4},
  pages={
          1775-82
        }
}
PURPOSE Normal aging is associated with accumulation of lipofuscin pigment in the retinal pigment epithelium (RPE). This may occur as a result of phagocytosis and incomplete degradation of oxidized photoreceptor outer segments (POS). This study was undertaken to determine whether phagocytosis of UV-irradiated POS (artificial lipofuscin) would increase expression in the RPE of various chemotactic and angiogenic cytokines. METHODS ARPE-19 cells were exposed to latex beads (0.76 micro m), naïve… CONTINUE READING
Highly Cited
This paper has 88 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Oxidative stress induced cellular signaling in RPE cells.

Frontiers in bioscience • 2012
View 8 Excerpts
Highly Influenced

89 Citations

051015'06'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 89 citations based on the available data.

See our FAQ for additional information.