Induction of angiogenesis in a mouse model using engineered transcription factors

  title={Induction of angiogenesis in a mouse model using engineered transcription factors},
  author={E. Rebar and Yan Huang and R. Hickey and A. Nath and D. Meoli and Sameer Nath and B. Chen and L. Xu and Y. Liang and A. Jamieson and L. Zhang and S. K. Spratt and C. Case and A. Wolffe and F. Giordano},
  journal={Nature Medicine},
The relationship between the structure of zinc-finger protein (ZFP) transcription factors and DNA sequence binding specificity has been extensively studied. Advances in this field have made it possible to design ZFPs de novo that will bind to specific targeted DNA sequences. It has been proposed that such designed ZFPs may eventually be useful in gene therapy. A principal advantage of this approach is that activation of an endogenous gene ensures expression of the natural array of splice… Expand
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