Induction of androgen receptor formation by epithelium-mesenchyme interaction in embryonic mouse mammary gland.

@article{Heuberger1982InductionOA,
  title={Induction of androgen receptor formation by epithelium-mesenchyme interaction in embryonic mouse mammary gland.},
  author={B Heuberger and I Fitzka and G Wasner and Klaus Kratochwil},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 9},
  pages={2957-61}
}
The role of tissue interaction in the development of hormone responsiveness was studied in the embryonic mammary gland of the mouse, which becomes sensitive to testosterone on day 14. Previously, the mesenchyme had been identified as the sole target tissue for the hormone, although it was also demonstrated that its response to testosterone required the presence of mammary epithelium. Using autoradiography, we now show that [3H]testosterone or [3H]5 alpha-dihydrotestosterone is bound only by… CONTINUE READING

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