Induction of an epithelial-mesenchymal transition by an in vivo adheron-like complex.

@article{Mjaatvedt1989InductionOA,
  title={Induction of an epithelial-mesenchymal transition by an in vivo adheron-like complex.},
  author={Corey H. Mjaatvedt and Roger R. Markwald},
  journal={Developmental biology},
  year={1989},
  volume={136 1},
  pages={118-28}
}
The embryonic vertebrate heart consists of two epithelia: the myocardium and endothelium, separated by the myocardial basement membrane (MBM). The myocardium has been shown to induce endothelial transformation into prevalvular mesenchyme in a temporally and site restricted manner. Previously, we hypothesized that the myocardial-endothelial interaction is mediated in vivo by aggregates of 30-nm particles in the MBM which can be removed by EDTA extraction. These MBM extracts contain fibronectin… CONTINUE READING
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