Induction of an effective anti-tumor immune response and tumor regression by combined administration of IL-18 and Apoptin

Abstract

Immunization strategies using plasmid DNA can potentially improve humoral and cellular immune responses that protect against cancer and infectious diseases. The chicken anemia virus-derived Apoptin protein exhibits remarkable specificity in its ability to induce apoptosis in tumor cells, but not in normal diploid cells. Interleukin-18 (IL-18) is a Th1-type… (More)
DOI: 10.1007/s00262-006-0178-y

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