Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responses.

Abstract

PURPOSE Cancer vaccines targeting tumor-associated antigens are being investigated for the therapy of tumors. Numerous strategies, including the direct intratumoral (i.t.) vaccination route, have been examined. For tumors expressing carcinoembryonic antigen (CEA) as a model tumor-associated antigen, we previously designed poxviral vectors that contain the… (More)

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