Induction of aldose reductase in cultured human microvascular endothelial cells by advanced glycation end products.

@article{Nakamura2000InductionOA,
  title={Induction of aldose reductase in cultured human microvascular endothelial cells by advanced glycation end products.},
  author={Naoto Nakamura and Hiroshi Obayashi and Masahiko Fujii and Michiaki Fukui and Kozo Yoshimori and Makiko Ogata and Goji Hasegawa and Hirofumi Shigeta and Yoshihiro Kitagawa and Toshikazu Yoshikawa and Masashi Kondo and Mitsuhiro Ohta and Masataka Nishimura and Toru Nishinaka and Chiaki Nishimura},
  journal={Free radical biology & medicine},
  year={2000},
  volume={29 1},
  pages={
          17-25
        }
}
Accelerated formation and accumulation of advanced glycation end products, as well as increased flux of glucose through polyol pathway, have been implicated in the pathogenesis of diabetic vascular complications. We investigated effects of advanced glycation end products on the levels of aldose reductase mRNA, protein, and activity in human microvascular endothelial cells. When endothelial cells were cultured with highly glycated bovine serum albumin, aldose reductase mRNA in endothelial cells… CONTINUE READING
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