Induction of aldose reductase expression in rat kidney mesangial cells and Chinese hamster ovary cells under hypertonic conditions.

@article{Kaneko1990InductionOA,
  title={Induction of aldose reductase expression in rat kidney mesangial cells and Chinese hamster ovary cells under hypertonic conditions.},
  author={Masatoshi Kaneko and Deborah A Carper and Cinthya Nishimura and Jenni E Millen and Michael Bock and Thomas C. Hohman},
  journal={Experimental cell research},
  year={1990},
  volume={188 1},
  pages={135-40}
}
Rat kidney cortex mesangial cells (MES) and Chinese hamster ovary cells (CHO) responded to hypertonicity (600 mosmol/kg) in culture by accumulating sorbitol. The accumulation of sorbitol was due to increased aldose reductase (AR) activity, apparently brought about by increased levels of AR mRNA and protein. The levels of AR mRNA increased approximately 60-fold in MES cells and 30-fold in CHO cells by 24 h in culture media (300 mosmol/kg supplemented with 150 mM NaCl, 600 mosmol/kg total). AR… CONTINUE READING

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