Induction of aggregation of Raji human B-lymphoblastic cells by vasoactive intestinal peptide.

@article{Robichon1993InductionOA,
  title={Induction of aggregation of Raji human B-lymphoblastic cells by vasoactive intestinal peptide.},
  author={A Robichon and Sunil P. Sreedharan and J Yang and Richard S. Shames and E C Gronroos and Pei Pei Cheng and Edward J. Goetzl},
  journal={Immunology},
  year={1993},
  volume={79 4},
  pages={574-9}
}
Subsets of neurons in the thymic cortex, Peyer's patches and lymphoid tissues of the respiratory system deliver vasoactive intestinal peptide (VIP) at nanomolar concentrations. The possible effects of VIP on B-cell adhesiveness in these tissues were examined in studies of the homotypic aggregation (HA) of human B-lymphoblastoid cells of the Raji line, which express a mean of 27,950 VIP receptors/cell with a mean Kd of 0.8 nM. Mean HA, assessed microscopically, attained a maximum of 54% after 8… CONTINUE READING
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