Induction of adipose-derived stem cell into motoneuron-like cells using selegiline as preinducer.

@article{Abdanipour2012InductionOA,
  title={Induction of adipose-derived stem cell into motoneuron-like cells using selegiline as preinducer.},
  author={Alireza Abdanipour and Taki Tiraihi},
  journal={Brain research},
  year={2012},
  volume={1440},
  pages={23-33}
}
Cell therapy is one of the approaches taken to treatment of spinal cord disorders. In this study, adipose-derived stem cells (ADSCs) were induced to form motoneuron-like cells (MNLCs) using selegiline as preinducer, as well as Shh and all trans-retinoic acid (RA) as inducers. Selegiline was reported to induce the embryonic stem cells and bone marrow stromal cells into neuronal phenotype. ADSCs were evaluated using CD90, CD44, CD 49d, CD106, CD31, CD45, lipogenesis and osteogenesis. Dose… CONTINUE READING
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