Induction of adhesion/differentiation of human neuroblastoma cells by tumour necrosis factor-alpha requires the expression of an inducible nitric oxide synthase.

@article{Obregn1997InductionOA,
  title={Induction of adhesion/differentiation of human neuroblastoma cells by tumour necrosis factor-alpha requires the expression of an inducible nitric oxide synthase.},
  author={Eva Obreg{\'o}n and M C Punz{\'o}n and Josefa Gonz{\'a}lez-Nic{\'o}las and E Fernandez-cruz and Manuel Rivas del Fresno and Ma {\'A}ngeles Mu{\~n}oz-Fern{\'a}ndez},
  journal={The European journal of neuroscience},
  year={1997},
  volume={9 6},
  pages={1184-93}
}
Neuroblastoma cell lines (SK-N-SH and SK-N-MC) were induced to differentiate, as detected by the expression of neurofilament proteins of 68 and 200 kDa, and to express adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule) after stimulation with tumour necrosis factor-alpha (TNF-alpha). This induction was accompanied by the arrest of cell growth. The induction of neuroblastoma adhesion by TNF-alpha could be inhibited by the nitric oxide synthase inhibitors, L… CONTINUE READING