Induction of acyl-CoA-binding protein and its mRNA in 3T3-L1 cells by insulin during preadipocyte-to-adipocyte differentiation.

@article{Hansen1991InductionOA,
  title={Induction of acyl-CoA-binding protein and its mRNA in 3T3-L1 cells by insulin during preadipocyte-to-adipocyte differentiation.},
  author={Henrik Ossipoff Hansen and Per Hove Andreasen and S Mandrup and Karsten Kristiansen and Jens Knudsen},
  journal={The Biochemical journal},
  year={1991},
  volume={277 ( Pt 2)},
  pages={341-4}
}
The induction of acyl-CoA-binding protein (ACBP) and ACBP mRNA was investigated in 3T3-L1 cells during growth and insulin-induced differentiation. The level of ACBP relative to both total soluble protein and DNA increased during insulin-stimulated conversion of 3T3-L1 cells from preadipocytes into fully developed adipocytes. So did the total rate of lipogenesis, as measured by incorporation of [1-14C]acetate. A similar increase in ACBP mRNA relative to total RNA was observed. These results… CONTINUE READING

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