Induction of actin cytoskeleton rearrangement by methyl okadaate--comparison with okadaic acid.

@article{Vilario2008InductionOA,
  title={Induction of actin cytoskeleton rearrangement by methyl okadaate--comparison with okadaic acid.},
  author={Natalia Vilari{\~n}o and Isabel R Ares and Eva Cagide and M. Carmen Louzao and Mercedes Rodr{\'i}guez Vieytes and Takeshi Yasumoto and Luis M. Botana},
  journal={The FEBS journal},
  year={2008},
  volume={275 5},
  pages={926-34}
}
Methyl okadaate is a derivative of the lipophilic polyether okadaic acid (OA), a well-known inducer of apoptosis. OA inhibits Ser/Thr protein phosphatases (PPs), among them types 1 and 2A (PP1 and PP2A), whereas methyl okadaate lacks PP1/PP2A inhibitory activity in vitro. As progressive loss of neuronal cytoarchitecture is a major event that precedes neuronal death, in this work we studied comparatively the effects of both toxins on actin cytoskeleton organization in human neuroblastoma cells… CONTINUE READING
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Degrada - tion and dephosphorylation of focal adhesion kinase during okadaic acid - induced apoptosis in human neuroblastoma cells

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