Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation.

@article{Zheng2008InductionOA,
  title={Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation.},
  author={Huarui Zheng and Lou Chang and Neha Patel and Jiong Yang and Lori Lowe and Dennis K. Burns and Yuan Zhu},
  journal={Cancer cell},
  year={2008},
  volume={13 2},
  pages={117-28}
}
Recent evidence suggests that alterations in the self-renewal program of stem/progenitor cells can cause tumorigenesis. By utilizing genetically engineered mouse models of neurofibromatosis type 1 (NF1), we demonstrated that plexiform neurofibroma, the only benign peripheral nerve sheath tumor with potential for malignant transformation, results from Nf1… CONTINUE READING