Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells

@article{Wright1990InductionOA,
  title={Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells},
  author={Nicholas Anthony Wright and Christine Pike and George Elia},
  journal={Nature},
  year={1990},
  volume={343},
  pages={82-85}
}
EPIDERMAL growth factor, and its human homologue urogastrone (EGF/URO)1, are secreted by the gut-associated salivary and Brunner's glands2,3. Recombinant EGF/URO is a powerful stimulator of cell proliferation and differentiation in the rodent4–7 and neonatal human8 intestine. But EGF/URO is not absorbed from the adult gut9,10 and has no action when given through the gut lumen6; thus the role of secreted EGF/URO is unknown. We now report that ulceration of the epithelium anywhere in the human… CONTINUE READING
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