Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression.

@article{Manni1996InductionOA,
  title={Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression.},
  author={Andrea Manni and Ellen Buckwalter and Ransome Etindi and S M Kunselman and Anna Rossini and David T. Mauger and David J Dabbs and Laurence M. Demers},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1996},
  volume={7 9},
  pages={
          1187-98
        }
}
To address the isoenzyme-specific involvement of protein kinase C (PKC) in breast cancer biology, hormone-responsive MCF-7 breast cancer cells were infected with either PKC-alpha or -beta 1 cDNAs subcloned in the retroviral expression vector pMV7. Several stable clones of PKC-overexpressing cells were generated. Western analysis revealed cross-regulation between the alpha and beta isoforms, because induction of overexpression of one up-regulated the other. Overexpression of the alpha and beta… CONTINUE READING

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