Induction of a hyperanxious state by antenatal dexamethasone: a case for less detrimental natural corticosteroids.

@article{Oliveira2006InductionOA,
  title={Induction of a hyperanxious state by antenatal dexamethasone: a case for less detrimental natural corticosteroids.},
  author={Mario de Oliveira and Jo{\~a}o Miguel Bessa and Ana R Mesquita and Hugo Tavares and Andre Carvalho and R. J. A. M. Silva and Jos{\'e} Miguel P{\^e}go and Jo{\~a}o Jos{\'e} Cerqueira and Joana Almeida Palha and Osborne F X Almeida and Nuno Sousa},
  journal={Biological psychiatry},
  year={2006},
  volume={59 9},
  pages={844-52}
}
BACKGROUND Synthetic glucocorticoids are commonly prescribed during pregnancy, despite a lack of systematic investigations of their potential impact on the developing brain and neurological and behavioral performance. METHODS Neuroendocrine parameters and behavior in the adult offspring of pregnant Wistar rats treated antenatally with either dexamethasone (DEX) or corticosterone (CORT) were monitored; DEX (.1 mg/kg and 1 mg/kg) and CORT (25 mg/kg) were given to pregnant rat dams on gestation… CONTINUE READING

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