Induction of a homeostatic circuit in lung tissue by microbial compounds.

@article{Takabayshi2006InductionOA,
  title={Induction of a homeostatic circuit in lung tissue by microbial compounds.},
  author={Kenji Takabayshi and M. Corr and Tomoko Hayashi and V. Redecke and L. Beck and D. Guiney and D. Sheppard and E. Raz},
  journal={Immunity},
  year={2006},
  volume={24 4},
  pages={
          475-87
        }
}
TGFbeta presented and activated by integrin alphavbeta6 expressed on alveolar epithelial cells (AEC) continuously inhibits the functionality of alveolar macrophages (AM). Despite this inhibition, AM retain their ability to respond to inhaled microorganisms. Herein we describe a homeostatic circuit through which the effects of microbial products on macrophages transiently circumvent this inhibition by repressing alphavbeta6 expression on AEC. Subsequent production of matrix metalloproteinases by… Expand
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