Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections.

@article{Miller2003InductionOA,
  title={Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections.},
  author={York E. Miller and Lori D. Dwyer-Nield and Robert L. Keith and Mysan Le and Wilbur A. Franklin and Alvin M. Malkinson},
  journal={Cancer letters},
  year={2003},
  volume={198 2},
  pages={139-44}
}
Murine pulmonary adenomas progress to malignancy with many similarities to human pulmonary adenocarcinoma, the most common form of lung cancer. Inbred mice vary in their susceptibility to lung tumor development, and induced genetic modifications are a powerful tool for understanding this susceptibility. Many transgenic and null mutations relevant to lung cancer pathogenesis were derived on the highly resistant C57BL/B6 (B6) background. Since the inability to reliably induce lung tumors in B6… CONTINUE READING

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