Induction of a fast-oxidative phenotype by chronic muscle stimulation: mechanical and biochemical studies.

@article{Jarvis1996InductionOA,
  title={Induction of a fast-oxidative phenotype by chronic muscle stimulation: mechanical and biochemical studies.},
  author={Jonathan C Jarvis and H. Sutherland and Caroline N. Mayne and Scott J. Gilroy and Stanley Salmons},
  journal={The American journal of physiology},
  year={1996},
  volume={270 1 Pt 1},
  pages={C306-12}
}
We studied changes in the mechanical properties and myosin isoform composition of rabbit tibialis anterior muscles that were subjected to continuous stimulation at 2.5 Hz for up to 12 wk. The effects of stimulation at 2.5 Hz were less profound than those observed for the same duration of stimulation at 10 Hz (12). Stimulation at 10 Hz for 12 wk induced complete transformation to a slow-contracting muscle homogeneous in slow myosin isoforms; stimulation for the same period at 2.5 Hz resulted in… CONTINUE READING